Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Antimicrobial activity of some novel 1-(1,3,4-oxadiazol-2-yl)-1Hbenzo[d]imidazolele substituted derivatives
Author(s): Neetu Soni, Namrata Soni and Pushpraj GuptaIn this study 12 benzmidazoles bearing oxadiazole moiety were synthesized in order to investigate their possible antibacterial and anti-fungal activities. Derivatives of benzimidazole were synthesized by nucleophilic substitution of 1H benzimidazoles with ethylchloroformate to yield acetate. The resulting acetate on the treatment with hydrazine hydrate and further with substituted carboxylic acid in the presence of phosphorous oxy chloride afforded corresponding oxadiazole derivatives. The structures of all compounds were established by IR, 1HNMR, 13C NMR and mass spectral data. Almost all newly synthesized compounds showed moderate to good antimicrobial activity.
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