Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Antimicrobial Activity of Newly Synthesized Thiadiazoles, 5-benzyl-2Htetrazole and Their Nucleosides
Author(s): Mamdouh A. Sofan, Samy B. Said, Said H. KandeelA number of new substituted tetrazole and their hydrazide derivatives as well as the corresponding sugar hydrazone derivatives were synthesized and tested for their antimicrobial activity against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gram-negative), and Streptomyces species (Actinomycetes) and antifungal activity against four fungal strains namely, Aspergillus flavus, Aspergillus fumigates, Penicillium marneffei and Trichophyton mentagrophytes. The synthesized compounds displayed different degrees of antimicrobial activity.
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