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Antimicrobial activities of synthesized and characterized 5-acetyl pyrimidine-2, 4, 6-(1H, 3H, 5H)-trione based chalcones | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Antimicrobial activities of synthesized and characterized 5-acetyl pyrimidine-2, 4, 6-(1H, 3H, 5H)-trione based chalcones

Author(s): Bhavesh D. Dhorajiya, Mahesh H. Malani, Jigar R. Patel and Bharat Z. Dholakiya

A series of eleven 5-((E)-3-phenylacryloyl) pyrimidine-2, 4, 6-(1H, 3H, 5H)-triones (5-acetyl pyrimidine 2, 4, 6-(1H, 3H, 5H) trione based chalcone) were synthesized using diethylmalonate, urea, acetic anhydride and various aryl aldehydes under basic conditions afforded the 5-acetyl pyrimidine-2, 4, 6-(1H, 3H, 5H)-trione based chalcone by means of Claisen–Schmidt condensation reaction. Furthermore, there has been some additional work investigating the effect of these derivatives on biological activity. They were characterized using FT-IR, 1H NMR spectroscopy and elemental analysis. The compounds show anti-fungal & antibacterial activity.


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