About nine number of mesalazine sulfonamides were synthesized by zeolite Y clay modified copper nitrate catalyzed solvent-free condensation of various substituted phenyl sulfonyl chloride and 5-amino salicylic acid under microwave irradiation. Their purities were examined by their physical constants, analytical and spectroscopic data. The antimicrobial activities of these sulfonamides have been studied using Bauer-Kirby disc-diffusion method.
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