Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Analytical method development and validation for simultaneous estimation of cinitapride and pantoprazole in pharmaceutical dosage form
Author(s): Keyur B Ahir, Dharti N Solanki*, Charmee B Gandhi, Harsh S Naik and Akshay S PatelA new, simple, precise, accurate, rapid as well as cost effective reverse phase HPLC method was developed for simultaneous estimation of cinitapride and pantoprazole in pharmaceutical dosage form. Chromatographic separation achieved isocratically on a C18 column by utilizing mobile phase Methanol: Water: Triethylamine (90: 10: 0.2v/v/v) at the flow rate of 1ml/min with UV detection at 277nm. The retention time of cinitpride and pantoprazole are 4.80min and 2.40min respectively. The method is accurate (99.2-102.9%), and linear within range 3-15μg/ml and 4-20μg/ml for ciitapride and pantoprazole respectively. The correlation coefficient was found to be r2= 0.999 and 0.997 for CNP and PNP respectively. The LOD for cinitapride and pantoprazole 0.223μg/ml and 0.498μg/ml respectively and LOQ are 0.675μg/ml and 1.509μg/ml respectively. The proposed method is applicable for routine analysis of simultaneous estimation of cinitapride and pantoprazole in combine pharmaceutical dosage form.
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Citations : 15261
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