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Analytical method development and validation for simultaneous estimation of cinitapride and pantoprazole in pharmaceutical dosage form | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Analytical method development and validation for simultaneous estimation of cinitapride and pantoprazole in pharmaceutical dosage form

Author(s): Keyur B Ahir, Dharti N Solanki*, Charmee B Gandhi, Harsh S Naik and Akshay S Patel

A new, simple, precise, accurate, rapid as well as cost effective reverse phase HPLC method was developed for simultaneous estimation of cinitapride and pantoprazole in pharmaceutical dosage form. Chromatographic separation achieved isocratically on a C18 column by utilizing mobile phase Methanol: Water: Triethylamine (90: 10: 0.2v/v/v) at the flow rate of 1ml/min with UV detection at 277nm. The retention time of cinitpride and pantoprazole are 4.80min and 2.40min respectively. The method is accurate (99.2-102.9%), and linear within range 3-15μg/ml and 4-20μg/ml for ciitapride and pantoprazole respectively. The correlation coefficient was found to be r2= 0.999 and 0.997 for CNP and PNP respectively. The LOD for cinitapride and pantoprazole 0.223μg/ml and 0.498μg/ml respectively and LOQ are 0.675μg/ml and 1.509μg/ml respectively. The proposed method is applicable for routine analysis of simultaneous estimation of cinitapride and pantoprazole in combine pharmaceutical dosage form.


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