Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
An Improved Synthesis, Characterization and Bioevalution of Schiff Base Containing Benzimidazole Moiety Catalyzed by Methane Sulfonic Acid
Author(s): Krishna Rao N, Surendra Babu MS, Ramana N, Tentu Nageswara Rao, Basaveswara Rao MV, Karri ApparaoIn present report an improved process for the synthesis for some novel Schiff bases from 2-amino benzimidazole with 5-substituted indole-3-carbaldehyde using methane sulfonic acid in free solvent at room temperature. The intermediate moiety (2-aminobenzimidazol) can be synthesized from o-phenyl diamine with cyanobromide in the presence of acid medium. All the newly synthesized compounds were confirmed by the advanced spectroscopic data (1H-NMR, 13C-NMR and LC-MS) and also structural determination were calculated by elemental analysis. In addition to all compounds were screened by their biological activities.
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Citations : 15261
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