Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
An Efficient and Versatile Method for Synthesis of 1,4-Dihydropyridines at Mild Reaction Conditions
Author(s): Sharda Goel, Vijender Goel, Anju BajwanHerein a simple, efficient, versatile and convenient Hantzsch method for synthesis of 1,4-dihydropyridines using ethylacetoacetate, ammonium acetate and substituted arylaldehydes in the presence of Tetrabutylammonium Hydrogen Sulfate (TBAHS) have been reported. Among the popular reported heterogenous solid catalysts, TBAHS has gained high popularity in organic synthesis due to its selectivity, inertness and thermal stability. The method offers advantages such as good to better yields, short reaction times, a simple work-up procedure, easy isolation of catalyst and reusability of catalyst for several runs.
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Citations : 15261
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