Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Al(DS)3 Catalyzed, One-pot Synthesis and Antibacterial Studies of tetra substituted 1,4-Dihydropyridines in Aqueous Media
Author(s): Harvinder Singh Sohal , Manvinder Kaur, Anu Radha Thakur and Priyanka ParmarMulti component, one pot synthesis of tetra substituted 1,4-dihydropyridine derivatives from the condensation of barbituric acid, methyl acetoacetate, aromatic aldehyde and ammonium acetate has been demonstrated using an highly efficient catalyst Aluminium tris(dodecyl sulphate) (Al(DS)3) in aqueous medium. The synthesized molecules were obtained in excellent yield and high purity without use of any additional methodology. Further, the synthesized compounds were found to exhibit potent antibacterial activity against various gram positive and gram negative bacterial strains as compared with the standard antibiotic drug (Amoxicillin).
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