Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
A simple HPLC method for quantitation of Emtricitabine in capsule dosage form
Author(s): Arjun Goje, Sathis Kumar. D, Yogeswaran. P, Sathyabrata Jena, David Banji, KNV RaoA simple, economic, accurate reverse phase isocratic RPHPLC method was developed for the quantitation of emtricitabine in capsule dosage form. The quantification was carried out using Gracesmart RP18, 5μ (100mm x 4.6mm). The mobile phase comprised of mixture of buffer, adjusted to pH 2.2 with dilute orthophosphoric acid and acetonitrile in the ratio of 88:12. The flow rate was 1.0ml/min with UV detection at 280nm. The method has been validated and proved to be robust. The calibration curve was linear in the concentration range of 50 to 500mcg/ml with coefficient of correlation 0.9981. The percentage recovery for emtricitabine was found to be 101.0%. The method is useful in the quality for the estimation of emtricitabine in capsule dosage form.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
