Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
A Rapid and Efficient Synthesis of 2,2',2''-(nitrilotris(ethane-2,1-diyl))tris(benzo [d][1,2]selenazol-3(2H)-one) and its Antioxidant Activity
Author(s): Devappa S. Lamani* and Mamata SinghIn the present communication an efficient method for the preparation of stable 2,2',2''-(nitrilotris(ethane-2,1-diyl)) tris(benzo[d][1,2]selenazol-3(2H)-one) has been developed. The reported compound benzoselenazol was achieved when 2, 2’-Selenobenzoyl chloride were treated with N,N-bis(2-aminoethyl)ethane-1,2-diamine over 1h. The reported structure was systematically characterized by 1H, 13C, 77Se NMR and mass spectroscopic techniques. In addition to synthesis and characterization the glutathione peroxidase (GPx) mimetic activity of newly synthesized compound were investigated. It is observed that the reported compound shows significant antioxidant activity in contrast with reference standard ebselen.
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