Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
A rapid and efficient route to synthesis of 2-amino-4H-pyran-3-carbonitrile derivatives in the presence of L-proline and their antimicrobial activity
Author(s): Anil Kumar Verma, Abha Bishnoi, Shaheen Fatma, Amrita Srivastava and Vineeta SinghAn efficient and mild method for the synthesis of 2-amino-4H-pyran-3-carbonitriles via coupling reaction of malononitrile and α,α’Bis(benzylidine) cyclohexanones in the presence of L-proline as a catalyst and acetonitrile as a solvent has been described. This method is a good option to obtain the title compounds in quantitative yields in shorter reaction times and in a simple way. The synthesized compounds were bio-evaluated for their possible antimicrobial activity against a panel of gram-positive and gram-negative bacterial strains and fungal strains by the known methods.
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Citations : 15261
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