Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
A note on the inhibition of steroid 11�Ž�²-hydroxylase, aldosterone synthase and aromatase by a series of coumarin derivatives
Author(s): Juan S. Gómez-Jeria, Gaston A. KpotinThe relationships between the inhibition of steroid 11β-hydroxylase, aldosterone synthase and aromatase enzymes and the electronic structure of a group of coumarin derivatives was analyzed. We obtained statistically significant results for the inhibition of the three enzymes. Some specific molecule-enzyme interactions are suggested. The corresponding pharmacophores were built. Finally, some suggestions that could improve the inhibitory capacity are proposed.
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Citations : 15261
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