Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.
Abstract
A new and concise synthetic route to enantiopure Linezolid from (S)-epichlorohydrin
Author(s): T Rajesh, G Madhusudhan, K Mukkanti, S P Narayana Rao and K Kishore BabuA new and short synthesis of Linezolid 1 has been emphasized in two path ways. The synthetic route in both the ways involves preparation of 2-((R)-3-(3-fluoro-4-morpholinophenylamino)-2- hydroxypropyl)isoindoline-1,3-dione 2 as a key intermediate starting from (S)-epichlorohydrin and phthalimide 3a. One of these methods involves the direct N-alkylation of 3-fluoro-4- morpholinobenzenamine 3b with 2-((S)-3-chloro-2-hydroxypropyl)isoindoline-1,3-dione 4a. Alternatively, compound 2 was prepared by using one-pot three step sequence via 2-(((S)-oxiran- 2-yl)methyl)isoindoline-1,3-dione 4b.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 25868
Der Pharma Chemica received 25868 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
DOWNLOADS
