Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
A New and Alternate Synthesis of Carvedilol: An Adrenergic receptor
Author(s): B.Anandkumar, R. Buchi Reddy, L. Gangaiah, G. Madhusudhan and K. MukkantiA New and alternate synthesis of carvedilol, β-adrenergic blocking agent is reported and finalized the meritorious one. The key step in this approach is synthesis of o-protected 1-(9Hcarbazol- 4-yloxy)-3-chloropropan-2-ol 6a, 6b, by protecting the alcohol group with acetyl and tertiarybutyldimethylsilylychloride protecting the group it is wished to report towards synthesis of Carvedilol 1 this approach is more efficient , improved overall yield, easy process and to avoid the process impurity like bis impurity Impurity B.
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