Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
A green approach for the heterocyclization of 2-substituted benzimidazoles: Synthesis, characterisation and pharmacological evaluation
Author(s): Hament Panwar*, Ranjana Dubey, Nidhi Chaudhary and Tilak RamSeveral 2-[5-(3-Methyl-1H-1,2,4-triazolyl) substituted benzylidenanilin-2-yl] benzimidazole (3a-f),2-[4-{(3-Methyl- 1H-1,2,4-triazolyl)-2-(2-substituted phenylthiazolidinon-3-yl)}phenyl] benzimidazole (4a-f) and 2-[{4-(3-Methyl- 1H-1,2,4-triazolyl) substituted piperazinyl phenyl}]benzimidazole (5a-c) have been synthesised by conventional synthesis and microwave methodology. The synthesized derivatives were characterized by IR, 1H-NMR, Mass and elemental analysis (C, H, N). Furthermore the synthesized benzimidazoles (3a-f), (4a-f) and (5a-c) were screened for antimicrobial, insecticidal and anthelmintic activities. The compound 4e displayed significant biological activities among the all synthesised derivatives and screened for the acute toxicity.
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