Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
A Facile synthesis of substituted quinolines by NaH mediated benzylic C-H functionalization of methyl aza-arenes and nucleophilic addition to aromatic aldehydes
Author(s): Suresh Budde, Jagadeesh Kumar Ega,Brahmeshwari Gavaji and Ravinder VaddeA method for synthesizing condensed quinolines by using NaH catalyzed A mixture of substituted methyl quinolines and Various aromatic aldehydes in the presence of THF solvents were successfully synthesized in excellent yields via C-C single bond formation. The quinoline ring derivatives widely used as has been found to possess antimalarial, anti-bacterial, antifungal, anthelmintic, cardiotonic, anticonvulsant, anti-inflammatory, and analgesic activity.
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Citations : 15261
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