Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
A facile construction of 5-methylazido-3-aryl 2-oxazolidinone: A key precursor for the synthesis of Linezolid
Author(s): G. Venkanna, G. Madhusudhan, K. Mukkanti, Y. Sampath kumar, K.VenuA facile construction of 5-methylazido-3-Aryl 2-Oxazolidinone is derived from various 1-azido-3-chloro-2-aryl/alkyl carbonates derivative and this extended to syntheses of Linezolid, an antibacterial agent are reported. The key step in the approached involves addition of 3- fluoro-4-morpholinobenzenamine with respective compounds by changing the leaving functionalities carbamate followed by formation of 2-oxazolidnone on other end and followed by functional group transformations yielded an antibacterial agent Linezolid. Process and less number of steps.
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Citations : 15261
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