Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
A facile and regioselective synthesis of Spiro pyrrolidines and pyrrolizines through 1, 3 -dipolar cycloaddition protocol
Author(s): T.Augustine Arul Prasad.,a B.Scholastica Mary Vithiya.,b* S.Ignacimuthu.c*Intermolecular 1, 3-dipolarcycloaddition reaction of azomethine ylides, generated through
decarboxylation route, with various substituted benzylidene acetophenone (Chalcones) as
dipolarophiles has been investigated. A new class of functionalized spiroheterocycles with
pyrrolidine and pyrrolizine framework has been synthesized with high regioselectivity. The
structures were established by spectroscopic techniques as well as single crystal X-ray analysis.
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Citations : 15261
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