Synthesis and pharmacological screening of some new derivatives of (Z)-[2-(2-substituted benzalamino-4-yl) hydrazono]-indolin-2-ones
By N. Raghunandan, M.Aruna Devi, D. Sriram and M. Sarangapani
Five different (Z)-3-[2-(2- aminooxazol-4-yl) hydrazono]-indolin-2-ones were synthesized from respective 3-[N-(chloroacetyl) hydrazono] indolin-2-one on reaction with urea. Each of that compound has refluxed with different aromatic aldehydes to get the respective (Z)-3-[2-(2-substituted benzalamino oxazol-4-yl)hydrazono]-indolin-2-ones. All the new derivatives of) (Z)-3-[2-(2-substituted benzalaminooxazol-4-yl) hydrazono]-indolin-2-ones were assayed for their antibacterial, antifungal, antioxidant and cytotoxic activities by standard methods.
Key words: (Z)-3-[2-(2-substituted benzalaminooxazol-4-yl] hydrazono]-indolin-2-ones, substituted benzaldehydes, Antibacterial activity, Antifungal activity, Antioxidant activity and Cytotoxic activity