Synthesis and biological activities of some novel substituted quinazoline derivatives
By K. Vijayakumar and A. Jafar Ahamed
A simple method for the synthesis of title compounds is reported, which were isolated from a series of reactions. After nucleophilic reaction of 2-phenyl-3, 1benzoxazin-4(3H)-one with thiosemicarbazide and hydrazinehydrate to furnish quinazolinylthiourea, followed by aromatic acidchloride, all the compounds synthesized were screened for their potential anticancer, anti-diabetic, anti tumor and anti asthmatic properties, which exhibited some authentic results towards testing organism in vitro and in vivo studies.
Key Words: anthranilic acid, thiosemicarbazide, hydrazinehydrate and benzoyl chloride