Synthesis of some biologically active benzothiazole derivatives
By Manish Chaudhary, Deepak Pareek, Pawan K. Pareek, Ravi Kant, Krishan G Ojha and Arun Pareek
N-(4,5-dihydro-1H-imidazol-2-yl)-6-substituted-1,3-benzothiazol-2-amines and N-(1H-benzimidazol-2-yl)-6-substituted-1,3-benzothiazol-2-amines were synthesized by the reaction of 6-substituted-2-aminobenzothiazoles with carbon disulphide and methyl iodide. It was followed by the reaction with o-phenylene diamine/ ethylene diamine. All the synthesized compounds were characterized by elemental analysis, IR spectra, 1H NMR and MASS spectral studies. They were screened for their anti-inflammatory, antiulcer, antitumor, entomological (antifeedant, acaricidal, contact toxicity and stomach toxicity) and antibacterial activities.
Keywords: Benzothiazole, Imidazoline, Benzimidazole, Anti-inflammatory, Antiulcer, Antitumor.