Enhancement of solubility of Rosiglitazone through solid dispersion technique: in-vitro and in-vivo permeation study analysis
By K. Punitha, Daisy Chella Kumari, V.Venkatesh Kumar, S. Suresh Kumar
The purpose of the study was to prepare solid dispersions of sparingly soluble drug Rosiglitazone by dispersion method with PGS and SSG as polymers to enhance the aqueous solubility of the drug and thereby bio availability. 12 batches of solid dispersions with two polymers (PGS, SSG) with varying drug: carrier ratios (1:1, 1:2, 1:4, 1:6, and 1:8 and 1:10) were prepared for optimization. All the formulation batches were subjected to phase solubility, IR diffraction, XRD, wettabilty, saturation solubility, assay, and in-vitro dissolution. Among the formulations batches that showed highest dissolutions R-PGS (1:1, 1:4) and R-SSG (1:1, 1:2) were selected and the in-vivo Permeation study in goat intestine was performed. FT-IR spectra indicated no interaction between the drug and the carriers in the dispersions. Reduced crystallinity of the drug was evident in the x-ray diffraction patterns. The decreased crystallinity of the dispersion along with decreased particle size, disaggregation of the particles, and increased wetability all accounts for the enhanced dissolution of the drug from solid dispersions.
Key words: - Solid dispersion, Rosiglitazone, PGS, SSG and in-vivo Permeation.