Novel spermicidal agent- A review
By Ankita Singh, Pramod Kumar Sharma, Nitin Kumar, Rupesh Dudhe and Shushank Dixit
Spermicides are chemical agents that immobilize/kill the spermatozoa in the vagina and exert their contraceptive effect in the female genital tract. Since most of the work on successful contraception concerns ova. However, recent clinical trials have shown that detergent spermicides do not provide any protection against STDs and AIDS but may in fact even promote their transmission. The most commonly used compound is the neutral surfactant nonoxynol-9. Other spermicidal products use either the structurally related compound octoxynol, or an alternative type of non-ionic surfactant, p-di-isobutyl-phenoxypolyethoxyethanol. Till no other natural or synthetic moieties are not available against sperms. Further recent advances are going on spermicidal activity in plants however success is not found. As it is suggested that sperm membrane sulfhydryl groups are important entities of the membrane and can be used as a tool for infertility assessment in unexplained male infertility and can be targeted for contraceptive research, we wanted to explore the sulfhydryl-binding agents.
Key words: Spermicidal, HIV, STD, Contraceptive, Surfactants.