One-pot multicomponent synthesis and antibacterial evaluation of some novel acridine derivatives
By Baseer M Shaikh, Shankaraiah G. Konda, Atul V. Mehare, Gajanan G. Mandawad, Santosh S . Chobe and Bhaskar S. Dawane
In the present communication a simple and efficient synthesis of some new acridines are described by the one-pot condensation of 3, 4, 9, 10-tetrahydroacridine-1(2H)-one, substituted aldehyde and liquor ammonia in alkaline polyethylene glycol (PEG-400) as green reaction solvent. The newly synthesized products were evaluated for their antibacterial and antifungal activity
Key words: Polyethylene glycol (PEG-400), 3,4,9,10-tetrahydroacridine-1(2H)-one, substituted aldehyde, antimicrobial activity.