Synthesis and antimicrobial activities of 2-azetidinone and its derivatives
By M. M. Murhekar and R. E. Khadsan
In present research work, 2-aminobenzothiazole is condensed with different aromatic aldehydes in ethanol to yield corresponding Schiff bases. The Schiff bases were cyclised with chloroacetyl choride in triethyl amine to yield the corresponding 2-Azetidinones. The structures of synthesized compounds were confirmed by elemental and spectral analysis such as IR, NMR, Mass, GC-MS. The compounds were evaluated for their antimicrobial properties against micro-organisms such as S. aureus, B. substilis, B megatherium, E. coli, S. typhi, P. aeruginosa.
Key words: 2 -Aminobenzothiazole, 2-azetidinone, schiff bases, antimicrobial activity.