Pharmacological Study of Some Newly Synthesized Furan Derivatives
By Sandip Sen, Biplab De, Lipika Panday, Trichy Siva Easwari, A.S.Nagarajan
Furan ring systems are abundantly available in secondary plant metabolites. Due to their remarkable properties, many synthetic furans are utilized as pharmaceuticals. Hence a series of N-(furan-2-ylmethylene) benz- imines derivatives has been synthesized by reaction between furan-2--carboxaldehyde and various aromatic anilines to yield the schiff,s bases. The newly synthesized compounds showed potent CNS depressant and analgesic activities. Prior to determination of the Pharmacological activity LD50 was determined. The pharmacological data obtained were tested for statistical significance.
Keywords : Furfuraldehyde, Column chromatography, PKaValue, LD50, Analgesic, CNS depressant.