Synthesis, characterization and antibacterial activity of some new 3-(aryl)-1-(4-(quinolin-8-ylamino)phenyl)prop-2-en-1-one
By Himani N. Chopde, Jyotsna S. Meshram, Ramakanth Pagadala, Venkateshwarlu Jetti
1-(4-(quinolin-8-ylamino)phenyl)ethanone (1) was synthesized from 4-aminoacetophenone and 8-hydroxyquinoline in presence of anhyd. ZnCl2. New chalcones (2) were synthesized from 1-(4-(quinolin-8-ylamino)phenyl)ethanone (1) and aromatic aldehydes under basic conditions via Claisen-Schmidt condensation. The structures of synthetic compounds were established on the basis of analytical and spectral data. These compounds were screened for their antibacterial activity.
Keywords : 4-aminoacetophenone, 8-hydroxyquinoline, chalcone, antibacterial activity.