Binding affinities of hydrophilic pulmonary surfactant proteins with surface proteins of microbes, pollen allergens and lipid ligands using molecular docking studies
By Y. Rambabu, K. Ramakrishna, Laxminarasu. M
Hydrophilic Surfactant proteins, SP-A and SP-D, are collagen like C-type (calcium dependent) lectins called collectins, which contribute significantly in host defence mechanism. Binding studies of SP-A and SP-D with the surface proteins of microorganisms, pollen allergens and lipid ligands were studied. Out of which SP-A was found to bind with a higher affinities with Influenza A- Virus (-542.48kcal/mol) and Di-lauroyl phosphatidyl choline (-114.622 kcal/mol) than SP-D, but Birch pollen allergen (-593.08kcal/mol) bound strongly with SP-D. Rotavirus and Carrot pollen allergen have negative binding with SP-A and positive binding with SP-D.
Keywords : Surfactant protein, Binding affinities, microbes, Pollen allergens, Lipids.