Synthesis and Antimicrobial Activity Some Novel N-[3-(Substituted Aryl)-1-Phenyl -1h-Pyrazol-4 Yl] Methylene Triazole Derivatives
By Jabali J. Vora, Dinesh R. Patel, Akash R. Patel, Yamini S. Patel
A simple and efficient synthesis of 2,4,6-triaryl pyridines is described by the one-pot condensation of substituted acetophenones, 1-phenyl-3-(4’-hydroxy/chloro phenyl) pyrazol-4-carboxaldehyde, ammonium acetate and solid sodium hydroxide in polyethylene glycol (PEG-400) as green reaction solvent. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.
Keywords : PEG-400, substituted acetophenones, 1-phenyl-3-(4’-hydroxy/chlorophenyl) pyrazol-4-carboxaldehyde, ammonium acetate, antimicrobial activity.