Novel and Rapid Estimation of Metronidazole in Tablets
By YN Manohara, R. Venkatesha Perumal, R. Revathi, Bahlul Z Awen
Simple aqueous titrimetric method is developed for the determination of metronidazole in tablets. The proposed method is based on the reduction of the nitro group to amino group of the molecule with zinc and 6M HCl. The reduced molecule was diazotised with sodium nitrite at 5-10oC. The reactions were carried out in aqueous medium without the use of organic solvents. This method was validated by low values of statistical parameters viz, standard deviation, related standard deviation and standard error of mean. This method is novel, accurate and economic and eco-friendly. The proposed method is recommended for quality control, routine analysis and developed for academic purpose.
Keywords : Metronidazole, Reduction and Diazotization.