Rapid, economical and green solid oxidation of sulfides to sulfoxides and their antimicrobial evaluation- part 1
By Anil M. Manikrao, Harish K. Kunjwani, Shrinivas D. Joshi, Niranjan S. Mahajan
A â€śgreenâ€? highly sensitive oxidation of organic sulfides, 3-(N-substituted carboxamido -ethylthio)-(4H)-1, 2, 4-triazoles (I a-k) to the corresponding sulfoxides (II a-k) was developed employing solid-state condition by using oxoneÂ®. The synthesized compounds were confirmed using elemental analysis and spectral data. These compounds were tested for their antibacterial and antifungal activities. None of them were found to possess any promising activity. This oxidation system is found clean, safe and operationally simple, environmentally friendly and meets the needs of contemporary â€śgreen chemistryâ€?.
Keywords : 3-(N-substituted carboxamidoethylthio)-(4H)-1, 2, 4-triazole, Oxidation, OxoneÂ®, Sulfoxide.