Simultaneous derivative and multicomponent spectrophotometric determination of Simvastatin and Ezetimibe in tablets
By Joshi H. V., J. K. Patel, Lata Kothapalli
Two new, simple, accurate and economical spectrophotometric methods have been developed for simultaneous estimation of simvastatin and ezetimibe in two component tablet formulation. The methods employed are first order derivative spectrophotometry using zero crossing techniques and multicomponent analysis both the drugs obey the Beer’s law in the concentration range employed for these methods. The results of analysis are validated statistical evaluation and recovery studies.
Keywords : Simvatatin, derivative spectrophotometry, multicomponent spectrophotometry, Ezetimibe.