Influence of Atorvastatin on the pharmacodynamics of Glipizide in normal and diabetic rat
By A.Mishra, R. Kumari, P. N. Murthy, P. P. Dash
This work reports the evaluation of the influence of atorvastatin on glipizide in normal and diabetic rats. Glipizide produced hypoglycemia activity in a dose dependent manner in normal and diabetic condition. In the presence of atorvastatin, glipizide produced early onset of action and maintained for longer period compared to glipizide group.
Keywords : Atorvastin, Glipizide, Hypoglycemia