Synthesis and evaluation of novel phthalimide derivatives as analgesic and antiinflammatory agents
By Rasika A. Pophale, Meenakshi N. Deodhar
A series of phthalimide derivatives were synthesized and evaluated for their analgesic and antiinflammatory activity. The synthesized compounds 3a-j were characterized by IR and NMR spectral data. All compounds were screened for their analgesic and antiinflammatory activity. Compounds 3a-j were screened for antiinflammatory activity against carrageenin induced rat paw edema. Except compound 3b all exhibited good antiinflammatory activity, while compounds 3d, 3h and 3j exhibited good analgesic activity when screened against acetic acid induced writhings in mice.
Keywords : phthalimide, pyrazoline, antiinflammatory, analgesic