Synthesis, characterization and antimicrobial screening of some novel 3, 5-diaryl-4H-1, 2, 4-triazole derivatives
By Ram Janam Singh
The syntheses of a series of 3, 5-diaryl-4H-1, 2, 4-triazole derivatives are described. A total of six new compounds were synthesized and characterized by IR, PMR, MS spectral data and elemental analyses. All newly synthesized compounds were screened for their antibacterial activity against S. aureus, E. coli, B. subtilis and P. aeruginosa. Compounds containing aryl substituents at position six and the 1, 2, 4- triazole moiety at position one or two showed reasonable antibacterial activity.
Keywords : 1, 2, 4-triazole, ethylbenzoatebenzoylhydrazone, hydrazine hydrate, antibacterial activity