Synthesis, characterization and anti-tumour activity of VOF3 and Cu (II) porphyrine complexes
By Fahmideh Shabani, Shahriar Ghammamy
Metal complexes of the ligand, 10, 15, 20-Tetra-p-tolyl-porphyrine abbreviated as H2TPP were prepared by reaction of salts of VOF3 and Cu (OAC) 2 with H2TPP in dry DMF. Characterization of the ligand and its complexes was made by microanalyses, FT-IR, 1H NMR and UV-Visible spectroscopy. These new complexes showed excellent anti-tumor activity against two kind of cancer cells that are K562 (human chronic myeloid leukemia) cells and Jurkat (human T lymphocyte carcinoma) cells.
Keywords : 10, 15, 20-Tetra-p-tolyl-porphyrine, H2TPP, VOF3, Cu (II), complex, anti-tumor activity against, K562, Jurkat.